Home » Uncategorized » Number Needed to Treat (NNT) Calculator

Number Needed to Treat (NNT) Calculator

Weaknesses of the NNT Metric

The idea of NNT provides clinicians with a method of explaining the relative benefit or harm of a given therapy for a patient. Because of its simplicity, NNT has the following weaknesses:

  1. It is usually described as a point estimate instead of a confidence interval of the observed therapeutic effect. This has led some authors to report NNT with a corresponding confidence interval (eg, NNT 5 (95% CI 3 to 9))
  2. As with other descriptions of benefit, NNT does not account for a patient’s baseline risk. If a patient’s individual risk is higher or lower than that studied in a trial, his or her NNT will be lower or higher, respectively.
  3. When describing NNT, the comparator is an essential component. The NNT of a given treatment will be very different when describing the value versus placebo instead of another active therapy.
  4. The time frame of a given study is important and the benefit of a treatment is usually not linear over time. For example, if a treatment was conducted over a mean of 4 years, its NNT should be expressed with the same time component (eg, 12 patients need to be treated over about 4 years…).

Number Needed to Treat (NNT) Calculator.


Inserisci i tuoi dati qui sotto o clicca su un'icona per effettuare l'accesso:

Logo di WordPress.com

Stai commentando usando il tuo account WordPress.com. Chiudi sessione /  Modifica )

Google photo

Stai commentando usando il tuo account Google. Chiudi sessione /  Modifica )

Foto Twitter

Stai commentando usando il tuo account Twitter. Chiudi sessione /  Modifica )

Foto di Facebook

Stai commentando usando il tuo account Facebook. Chiudi sessione /  Modifica )

Connessione a %s...